HEMOPHILIA INHIBITOR PATIENTS: THE USE OF RECOMBINANT FACTOR VIIa

Autor: Dušan Andoljšek, Samo Zver
Jazyk: English<br />Slovenian
Rok vydání: 2004
Předmět:
Zdroj: Zdravniški Vestnik, Vol 73, Iss 0 (2004)
Druh dokumentu: article
ISSN: 1318-0347
1581-0224
Popis: Background. Recombinant factor VIIa can induce hemostasis and controls bleeding in surgery in hemophilia inhibitor patients and in other hemostatic disorders, e.g. thrombocytopenia, platelet function disorders, coagulation disorders due to drugs and liver disease, in trauma and surgical patients. We describe the use of rF VIIa in bleeding episodes and surgery in four hemophilia A inhibitor patients.Patients and methods. We used rF VIIa in 6 bleeding episodes and in 3 surgical procedures (intracerebral and subdural hematoma, hematoma of the sculp) in four hemophilia inhibitor patients. 90 µg/kg b.w. rF VIIa was given every 2 hours for 24–82 hours, then the time interval was gradually changed to 6 hours.The treatement duration depends on the site and severity of bleeding and surgery. The traditional assays are not suitable for monitoring the hemostatic effect of rF VIIa.Results and discussion. The reason for rF VIIa treatement were inhibitors in hemophilia, necessity for treatement for several days and surgery. In muscle, joint, gastrointestinal bleeding rF VIIa was effective but not in hematuria and thoracic wall bleeding with haemorhagic shock. The surgery itself went smoothly.Conclusions. rF VIIa controls spontaneous and posttraumatic bleedings, even the longlasting ones in hemophilia A (and B) patients with inhibitors. It prevents bleeding in major surgery. Adult patients should be treated first with standard doses of 90 µg/kg b.w. every 2 hrs for 24–48 hrs. Than time interval is gradually prologed to 6 hrs. The traditional assays are not suitable for monitoring the hemostatic effect of rF VIIa. Close monitoring is required in all patients to determine efficacy and insure safety of treatement.
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