| Autor: |
Yabing Xiong, Xiaolong Li, Jiafeng Liu, Pei Luo, Haixia Zhang, Hong Zhou, Xian Ling, Meijia Zhang, Ye Liang, Qiurong Chen, Chaofeng Xing, Fanghong Li, Jinhua Miao, Weiwei Shen, Shan Zhou, Xiaoxu Wang, Fan Fan Hou, Youhua Liu, Kunling Ma, Allan Zijian Zhao, Lili Zhou |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Pharmacological Research, Vol 208, Iss , Pp 107384- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1096-1186 |
| DOI: |
10.1016/j.phrs.2024.107384 |
| Popis: |
Energy metabolism disorder, mainly exhibiting the inhibition of fatty acid degradation and lipid accumulation, is highly related with aging acceleration. However, the intervention measures are deficient. Here, we reported Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs), especially EPA, exerted beneficial effects on maintaining energy metabolism and lipid homeostasis to slow organ aging. As the endogenous agonist of peroxisome proliferator–activated receptor α (PPARα), Omega-3 PUFAs significantly boosted fatty acid β-oxidation and ATP production in multiple aged organs. Consequently, Omega-3 PUFAs effectively inhibited age-related pathological changes, preserved organ function, and retarded aging process. The beneficial effects of Omega-3 PUFAs were also testified in mfat-1 transgenic mice, which spontaneously generate abundant endogenous Omega-3 PUFAs. In conclusion, our study innovatively demonstrated Omega-3 PUFAs administration in diet slow aging through promoting energy metabolism. The supplement of Omega-3 PUFAs or fat-1 transgene provides a promising therapeutic approach to promote healthy aging in the elderly. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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