Timing of Recanalization and Functional Recovery in Acute Ischemic Stroke
| Autor: | Georgios Tsivgoulis, Maher Saqqur, Vijay K. Sharma, Alejandro Brunser, Jürgen Eggers, Robert Mikulik, Aristeidis H. Katsanos, Theodore N. Sergentanis, Konstantinos Vadikolias, Fabienne Perren, Marta Rubiera, Reza Bavarsad Shahripour, Huy Thang Nguyen, Patricia Martínez-Sánchez, Apostolos Safouris, Ioannis Heliopoulos, Ashfaq Shuaib, Carol Derksen, Konstantinos Voumvourakis, Theodora Psaltopoulou, Anne W. Alexandrov, Andrei V. Alexandrov |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Journal of Stroke, Vol 22, Iss 1, Pp 130-140 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2287-6391 2287-6405 |
| DOI: | 10.5853/jos.2019.01648 |
| Popis: | Background and Purpose Although onset-to-treatment time is associated with early clinical recovery in acute ischemic stroke (AIS) patients treated with intravenous tissue plasminogen activator (tPA), the effect of the timing of tPA-induced recanalization on functional outcomes remains debatable. Methods We conducted a multicenter, prospective observational cohort study to determine whether early (within 1-hour from tPA-bolus) complete or partial recanalization assessed during 2-hour real-time transcranial Doppler monitoring is associated with improved outcomes in patients with proximal occlusions. Outcome events included dramatic clinical recovery (DCR) within 2 and 24-hours from tPA-bolus, 3-month mortality, favorable functional outcome (FFO) and functional independence (FI) defined as modified Rankin Scale (mRS) scores of 0–1 and 0–2 respectively. Results We enrolled 480 AIS patients (mean age 66±15 years, 60% men, baseline National Institutes of Health Stroke Scale score 15). Patients with early recanalization (53%) had significantly (jos-2019-01648P |
| Databáze: | Directory of Open Access Journals |
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