Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates

Autor: Vida Chitsazzadeh, Cristian Coarfa, Jennifer A. Drummond, Tri Nguyen, Aaron Joseph, Suneel Chilukuri, Elizabeth Charpiot, Charles H. Adelmann, Grace Ching, Tran N. Nguyen, Courtney Nicholas, Valencia D. Thomas, Michael Migden, Deborah MacFarlane, Erika Thompson, Jianjun Shen, Yoko Takata, Kayla McNiece, Maxim A. Polansky, Hussein A. Abbas, Kimal Rajapakshe, Adam Gower, Avrum Spira, Kyle R. Covington, Weimin Xiao, Preethi Gunaratne, Curtis Pickering, Mitchell Frederick, Jeffrey N. Myers, Li Shen, Hui Yao, Xiaoping Su, Ronald P. Rapini, David A. Wheeler, Ernest T. Hawk, Elsa R. Flores, Kenneth Y. Tsai
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms12601
Popis: Cutaneous squamous cell of the skin is a common neoplasm that frequently arises from precancerous actinic keratoses. Here, the authors carry out genomic analysis on matched sets of human lesions and compare with those in ultraviolet treated mice and identify conserved drivers of tumour development.
Databáze: Directory of Open Access Journals