MEASUREMENT OF PROCALCITONIN IN THE CEREBROSPINAL FLUID FOR DIFFERENTIAL DIAGNOSTICS IN CHILDREN WITH MENINGITIS
| Autor: | L. N. Mazankova, G. D. Guseva, D. A. Moiseenkova, T. N. Molotilova, N. I. Aleshina |
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| Jazyk: | ruština |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Alʹmanah Kliničeskoj Mediciny, Vol 0, Iss 42, Pp 96-102 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2072-0505 2587-9294 |
| DOI: | 10.18786/2072-0505-2015-42-96-102 |
| Popis: | Background: High production of pro-inflammatory cytokines associated with procalcitonin synthesis and its increased blood levels play an important role in the pathophysiology of systemic inflammation in generalized bacterial infections. Aim: To assess diagnostic value of procalcitonin measurement as a marker of bacterial inflammation in cerebrospinal fluid for differential diagnostics of bacterial and viral meningitis. Materials and methods: Procalcitonin levels in blood and cerebrospinal fluid were measured by immunoenzyme analysis in 88 children aged from 3 months to 14 years who had been admitted to the hospital. Forty five percent (45.4%) of them had acute bacterial meningitis, 27.3%, viral meningitis and 27.3% had the meningitis-like syndrome (control group). Results: There was a high procalcitonin level in cerebrospinal fluid in patients with bacterial purulent meningitis (0,14 [0.0; 0.34] ng/mL (р < 0.006), with the normal range in the control group of 0.07 [0.0; 0.07] ng/mL. This parameter correlated with blood procalcitonin level (9.8 [2.05; 13.19] ng/mL) and severity of meningitis. In patients with viral meningitis, the procalcitonin levels were below the normal range (0.02 [0.01; 0.07] ng/mL). Conclusion: Measurement of procalcitonin levels in cerebrospinal fluid could be recommended for inclusion into the differential diagnostic algorithm of meningitis of various etiologies in children. |
| Databáze: | Directory of Open Access Journals |
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