Crohn’s Disease Associated Pyoderma Gangrenosum Treated with Adalimumab
| Autor: | Despoina Kakagia, Eleni Efremidou, Nikolaos Lyratzopoulos, Alexandros Mitrakas, Michael Pitiakoudis, George Kouklakis |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Balkan Medical Journal, Vol 29, Iss 1, Pp 93-95 (2012) |
| Druh dokumentu: | article |
| ISSN: | 2146-3123 2146-3131 |
| Popis: | Pyoderma gangrenosum is a known, though infrequent, ulcerative skin lesion that is often associated with systemic inflammatory and immunologic diseases. Objective: To present the efficacy of Adalimumab, a fully human Tumour Necrosis Factor-α antagonist, in the treatment of pyoderma gangrenosum associated with Crohn’s disease. Methods: A young male patient with pyoderma gangrenosum of the shin as the first sign of clinically active Crohn’s disease, who was treated with Adalimumab, is herein presented. Results: Almost complete healing of the lesion was achieved after 12 weeks of treatment. Conclusions: Successful treatment outcome suggests that Adalimumab is not only a therapeutic option for Crohn’s disease but may also be a safe and effective therapy for Pyoderma gangrenosum associated with the disease. Pyoderma gangrenosum should be suspected in any cutaneous ulcerative lesion occurring in patients with Crohn’s disease. |
| Databáze: | Directory of Open Access Journals |
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