Late presentation of chronic myeloid leukaemia patients in a low-income country: the prognostic implications and impact on treatment outcome

Autor: Elisha A. Nelson, Ibrahim O. Ahmed, Rahman A. Bolarinwa, Babatunde A. Adeagbo, Adebanjo J. Adegbola, Lateef Salawu, Oluseye O. Bolaji, Muheez A. Durosinmi
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMC Research Notes, Vol 17, Iss 1, Pp 1-7 (2024)
Druh dokumentu: article
ISSN: 1756-0500
DOI: 10.1186/s13104-024-06910-9
Popis: Abstract Background In Nigeria, since 2002, Imatinib mesylate (glivec®) has been available freely to chronic myeloid leukaemia (CML) patients but only at a tertiary health care centre in the southwestern part of the country. Despite this, it is not readily accessible to many patients due to the distance and other challenges including low socioeconomic status and political problems, preventing timely access to specialist care. This study evaluated the effect of the baseline characteristics on the prognostic implication and treatment outcome of CML patients in Nigeria. Method This study retrospectively evaluated the baseline characteristics, clinical presentations and treatment outcomes of 889 CML patients over 18 years (2002–2020). Of these, 576 (65%) patients had complete information with up-to-date BCR::ABL1 records. These 576 patients were categorized based on their responses to Imatinib therapy into three groups viz.; Optimal response (OR) defined as BCR::ABL1 ratio of
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje