| Autor: |
Ming-liang Ji, Hua Jiang, Zhuang Li, Rui Geng, Jun Zheng Hu, Yu Cheng Lin, Jun Lu |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-022-35424-w |
| Popis: |
Ji and colleagues identify Sirt6 as a regulator of chondrocyte senescence. Mechanistically, Sirt6 physically interacts with STAT5 and deacetylates it at K163, which reduces the IL-15/JAK3-induced STAT5 translocation from cytoplasm to nucleus. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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