SYSTEMIC HEMOSTATIC AND PROTHROMBOTIC EFFECTS OF FIBRIN-MONOMER IN EXPERIMENT WITH DOSED LIVER THERAPY
| Autor: | A. P. Momot, V. M. Vdovin, I. I. Shakhmatov, I. G. Tolstokorov, D. A. Orekhov, V. O. Shevchenko, N. A. Lycheva, A. V. Kudinov, G. G. Belozerskaya, V. I. Kiselev |
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| Jazyk: | ruština |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Сибирский научный медицинский журнал, Vol 39, Iss 1, Pp 6-12 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2410-2512 2410-2520 |
| DOI: | 10.15372/SSMJ20190101 |
| Popis: | Objective of the study is to experimentally evaluate system hemostatic and prothrombotic effects of intravenous fibrin monomer (FM). Materials and methods. Eighty two Chinchilla rabbits weighing 3–4 kg were used in the study. In addition to the placebo, animals were administered an aqueous solution of fibrin monomer (FM) intravenously at doses of 0.1, 0.25, 0.5, 1.0, 2.5 and 5.0 mg/kg. After 1 hour, a standard liver injury was performed and the blood loss (% of the circulating blood volume) resulting from parenchymal hemorrhage was estimated. Hemostatic system examination included platelet number in venous blood and fibrinogen and D-dimer levels in blood plasma. Results and discussion. Blood loss after dosed injury with placebo was 10.0 [4.0; 15.7] % blood volume (median [25th percentile; 75th percentile]). FM preparation doses of 0.25, 2.5 and 5.0 mg/kg resulted in a decrease of blood loss by 6.3 (p < 0.001), 7.8 (p |
| Databáze: | Directory of Open Access Journals |
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