| Autor: |
Joseph C Y Liu, Janice M Leung, David A Ngan, Negar F Nashta, Silvia Guillemi, Marianne Harris, Viviane D Lima, Soo-Jung Um, Yuexin Li, Sheena Tam, Tawimas Shaipanich, Rekha Raju, Cameron Hague, Jonathon A Leipsic, Jean Bourbeau, Wan C Tan, P Richard Harrigan, Don D Sin, Julio Montaner, S F Paul Man |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 10, Iss 4, p e0124426 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0124426 |
| Popis: |
Combination antiretroviral therapy (cART) has extended the longevity of human immunodeficiency virus (HIV)-infected individuals. However, this has resulted in greater awareness of age-associated diseases such as chronic obstructive pulmonary disease (COPD). Accelerated cellular senescence may be responsible, but its magnitude as measured by leukocyte telomere length is unknown and its relationship to HIV-associated COPD has not yet been established. We measured absolute telomere length (aTL) in peripheral leukocytes from 231 HIV-infected adults. Comparisons were made to 691 HIV-uninfected individuals from a population-based sample. Subject quartiles of aTL were assessed for relationships with measures of HIV disease severity, airflow obstruction, and emphysema severity on computed tomographic (CT) imaging. Multivariable regression models identified factors associated with shortened aTL. Compared to HIV-uninfected subjects, the mean aTL in HIV-infected patients was markedly shorter by 27 kbp/genome (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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