Immunosuppressors and immunomodulators in Neurology - Part I: a guide for management of patients underimmunotherapy

Autor: Fabiano Ferreira Abrantes, Marianna Pinheiro Moraes de Moraes, José Marcos Vieira de Albuquerque Filho, Jéssica Monique Dias Alencar, Alexandre Bussinger Lopes, Wladimir Bocca Vieira de Rezende Pinto, Paulo Victor Sgobbi de Souza, Enedina Maria Lobato de Oliveira, Acary de Souza Bulle de Oliveira, José Luiz Pedroso, Orlando Graziani Povoas Barsottini
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Arquivos de Neuro-Psiquiatria, Vol 79, Iss 11, Pp 1012-1025 (2021)
Druh dokumentu: article
ISSN: 1678-4227
0004-282x
DOI: 10.1590/0004-282x-anp-2020-0593
Popis: ABSTRACT For patients with autoimmune diseases, the risks and benefits of immunosuppressive or immunomodulatory treatment are a matter of continual concern. Knowledge of the follow-up routine for each drug is crucial, in order to attain better outcomes and avoid new disease activity or occurrence of adverse effects. To achieve control of autoimmune diseases, immunosuppressive and immunomodulatory drugs act on different pathways of the immune response. Knowledge of the mechanisms of action of these drugs and their recommended doses, adverse reactions and risks of infection and malignancy is essential for safe treatment. Each drug has a specific safety profile, and management should be adapted for different circumstances during the treatment. Primary prophylaxis for opportunistic infections and vaccination are indispensable steps during the treatment plan, given that these prevent potential severe infectious complications. General neurologists frequently prescribe immunosuppressive and immunomodulatory drugs, and awareness of the characteristics of each drug is crucial for treatment success. Implementation of a routine before, during and after use of these drugs avoids treatment-related complications and enables superior disease control.
Databáze: Directory of Open Access Journals
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