Autor: |
Zhang Mao, Zhu Wen-ting, Wang Hai-tao, Yu Hui, Lan Shi-yi, Xu Jiang-ping, Wang Wen-ya |
Jazyk: |
angličtina |
Rok vydání: |
2020 |
Předmět: |
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Zdroj: |
Frontiers in Molecular Neuroscience, Vol 13 (2020) |
Druh dokumentu: |
article |
ISSN: |
1662-5099 |
DOI: |
10.3389/fnmol.2020.00165 |
Popis: |
Dopaminergic neuronal loss is the main pathological character of Parkinson’s disease (PD). Abnormal tau hyperphosphorylation will lead to dopaminergic neuronal loss. An indazole derivative 6-amino-1-methyl-indazole (AMI) successfully synthesized to inhibit tau hyperphosphorylation may exert a neuroprotective effect. The in vitro study showed that AMI effectively increased cell viability and alleviated the apoptosis induced by MPP+ in SH-SY5Y cells. In addition, AMI treatment significantly decreased the expression of p-tau and upstream kinases GSK-3β. In the MPTP-induced PD mice models, we found AMI apparently preserved dopaminergic neurons in the substantia nigra and improved the PD behavioral symptoms. Our results demonstrate that AMI exerts a neuroprotective effect by inhibiting tau hyperphosphorylation, representing a promising new candidate for PD treatment. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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