Biomarkers Associated with Death After Initiating Treatment for Tuberculosis and HIV in Patients with Very Low CD4 Cells

Autor: Fred Richard Sattler, Daniel Chelliah, Xingye Wu, Alejandro Sanchez, Michelle A. Kendall, Evelyn Hogg, David Lagat, Umesh Lalloo, Valdilea Veloso, Diane V. Havlir, Alan Landay
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Pathogens and Immunity, Vol 3, Iss 1, Pp 46-62 (2018)
Druh dokumentu: article
ISSN: 2469-2964
DOI: 10.20411/pai.v3i1.235
Popis: Background: The risk of short-term death for treatment naive patients dually infected with Mycobacterium tuberculosis and HIV may be reduced by early anti-retroviral therapy. Of those dying, mechanisms responsible for fatal outcomes are unclear. We hypothesized that greater malnutrition and/or inflammation when initiating treatment are associated with an increased risk for death. Methods: We utilized a retrospective case-cohort design among participants of the ACTG A5221 study who had baseline CD4
Databáze: Directory of Open Access Journals