Autor: |
Aruni Ghose, Sri Vidya Niharika Gullapalli, Naila Chohan, Anita Bolina, Michele Moschetta, Elie Rassy, Stergios Boussios |
Jazyk: |
angličtina |
Rok vydání: |
2022 |
Předmět: |
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Zdroj: |
Proteomes, Vol 10, Iss 2, p 16 (2022) |
Druh dokumentu: |
article |
ISSN: |
2227-7382 |
DOI: |
10.3390/proteomes10020016 |
Popis: |
The ability to identify ovarian cancer (OC) at its earliest stages remains a challenge. The patients present an advanced stage at diagnosis. This heterogeneous disease has distinguishable etiology and molecular biology. Next-generation sequencing changed clinical diagnostic testing, allowing assessment of multiple genes, simultaneously, in a faster and cheaper manner than sequential single gene analysis. Technologies of proteomics, such as mass spectrometry (MS) and protein array analysis, have advanced the dissection of the underlying molecular signaling events and the proteomic characterization of OC. Proteomics analysis of OC, as well as their adaptive responses to therapy, can uncover new therapeutic choices, which can reduce the emergence of drug resistance and potentially improve patient outcomes. There is an urgent need to better understand how the genomic and epigenomic heterogeneity intrinsic to OC is reflected at the protein level, and how this information could potentially lead to prolonged survival. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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