Effect modification of polypharmacy on incident frailty by chronic kidney disease in older adults

Autor: Nina Mielke, Muhammad Helmi Barghouth, Anne-Katrin Fietz, Cédric Villain, Tim Bothe, Natalie Ebert, Elke Schaeffner
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMC Geriatrics, Vol 24, Iss 1, Pp 1-11 (2024)
Druh dokumentu: article
ISSN: 1471-2318
DOI: 10.1186/s12877-024-04887-5
Popis: Abstract Background Frailty and polypharmacy are common conditions in older adults, especially in those with chronic kidney disease (CKD). Therefore, we analyzed the association of polypharmacy and incident frailty and the effect modification by CKD in very old adults. Methods In non-frail individuals within the Berlin Initiative (cohort) Study, polypharmacy (≥ 5 medications) was assessed according to multiple definitions based on the number of regular and on demand prescription and over the counter drugs, as well as vitamins and supplements. CKD was defined as an estimated glomerular filtration rate
Databáze: Directory of Open Access Journals