Assessment of Antifungal Pharmacodynamics

Autor:	Alex Howard, William Hope
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	antifungal pharmacokinetics pharmacodynamics translational clinical efficacy Biology (General) QH301-705.5
Zdroj:	Journal of Fungi, Vol 9, Iss 2, p 192 (2023)
Druh dokumentu:	article
ISSN:	2309-608X
DOI:	10.3390/jof9020192
Popis:	Pharmacokinetic-pharmacodynamic (PK-PD) analysis is of central importance to the progress of an antifungal agent into clinical use. It is crucial to ensure that preclinical studies give the best possible prediction of the way drugs are likely to behave in a clinical setting. This review details the last 30 years of progress in terms of disease model design, efficacy outcome selection and translational modelling in antifungal PK-PD studies. The principles of how PK-PD parameters inform current clinical practice are also discussed, including a review of how these apply to existing and novel agents.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/2290d2c39be849ca8349c0b0bb971aef Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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