Nuclear-cytoplasmic Shuttling in Chronic Myeloid Leukemia: Implications in Leukemia Maintenance and Therapy

Autor:	Giovanna Carrà, Isabella Russo, Angelo Guerrasio, Alessandro Morotti
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	nuclear-cytoplasmic shuttling chronic myeloid leukemia bcr-abl mirna pten p53 Cytology QH573-671
Zdroj:	Cells, Vol 8, Iss 10, p 1248 (2019)
Druh dokumentu:	article
ISSN:	2073-4409
DOI:	10.3390/cells8101248
Popis:	Nuclear-cytoplasmic shuttling is a highly regulated and complex process, which involves both proteins and nucleic acids. Changes in cellular compartmentalization of various proteins, including oncogenes and tumor suppressors, affect cellular behavior, promoting or inhibiting proliferation, apoptosis and sensitivity to therapies. In this review, we will recapitulate the role of various shuttling components in Chronic Myeloid Leukemia and we will provide insights on the potential role of shuttling proteins as therapeutic targets.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/228b044e2d054b9c8482736020564d3e Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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