Oxicam-type non-steroidal anti-inflammatory drugs inhibit NPR1-mediated salicylic acid pathway

Autor: Nobuaki Ishihama, Seung-won Choi, Yoshiteru Noutoshi, Ivana Saska, Shuta Asai, Kaori Takizawa, Sheng Yang He, Hiroyuki Osada, Ken Shirasu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-27489-w
Popis: The plant defense hormone salicylic acid has structural similarity to oxicam-type non-steroidal antiinflammatories. Here the authors show oxicams, as well as endogenous salicylic acid, can alter cellular redox state and immune signaling without affecting the redox status of cysteines in NPR1.
Databáze: Directory of Open Access Journals