One‐pot synthesis chlorin e6 nano‐precipitation for colorectal cancer treatment Ce6 NPs for colorectal cancer treatment

Autor: Zhongxing Miao, Yujie Wang, Shengjie Li, Min Zhang, Meng Xu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: IET Nanobiotechnology, Vol 15, Iss 8, Pp 680-685 (2021)
Druh dokumentu: article
ISSN: 1751-875X
1751-8741
DOI: 10.1049/nbt2.12065
Popis: Abstract The drug nanoparticles free of additional carriers hold great promise in drug delivery and are suitable for the therapy of cancers. Herein, we developed a one‐pot method to prepare chlorin e6 (Ce6) nano‐precipitations (Ce6 NPs) for effective photodynamic therapy of colorectal cancer. The drug loading of Ce6 NPs was around 81% and showed acceptable stability, high biocompatibility as well as effective reactive oxygen species (ROS) generation capability. As a result, the Ce6 NPs can produce significantly elevated ROS upon laser irradiations and achieved better anticancer benefits than free Ce6.
Databáze: Directory of Open Access Journals
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