| Autor: |
João Caria, Ana C. Gonçalves, Gonçalo Cristóvão, Maria Carlos, Sara Magalhães, Vasco Almeida, Fernanda Moreno, Élia Mateus, Hélder Pinheiro, Diana Póvoas, Fernando M.T. Maltez, Rui Perdigoto, Filipe S. Cardoso, Hugo P. Marques |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
GE: Portuguese Journal of Gastroenterology, Pp 1-7 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2387-1954 |
| DOI: |
10.1159/000539690 |
| Popis: |
Introduction: Carbapenem-resistant Enterobacteriaceae (CRE) epidemiology among liver transplant (LT) recipients is variable. We studied the impact of CRE colonization and infection on LT recipients’ outcomes. Methods: This observational cohort study included consecutive adult LT recipients between January 2019 and December 2020 at Curry Cabral Hospital, Lisbon, Portugal. Primary exposures were CRE colonization (rectal swabs under a screening program) and infection within 1 year of index LT. Primary endpoint was graft failure within 1 year of the index LT. Results: Among 209 patients, the median (interquartile range [IQR]) age was 57 (47–64) years and 155 (74.2%) were male. CRE colonization was identified in 28 (13.4%) patients during the first year posttransplant (median [IQR] number of rectal swabs per patient of 4 [2–7]). CRE resistance genes identified were OXA48 in 8 (3.6%) patients, KPC in 19 (67.9%) patients, and VIM in 1 (3.6%) patient. Any bacterial/fungal and CRE infections were diagnosed in 88 (42.1%) and 6 (2.9%) patients, respectively, during the first year posttransplant. After adjusting for confounders, neither CRE colonization (aOR [95% CI] = 1.83 [0.71–4.70]; p = 0.21) nor infection (aOR [95% CI] = 1.35 [0.17–11.06]; p = 0.78) was associated with graft failure within 1 year of index LT. Discussion/Conclusion: Under a screening program, CRE colonization and infection prevalence was low and neither was associated with graft failure. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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