Expression of soluble ST2 in patients with essential hypertension and its relationship with left ventricular hypertrophy

Autor: Peng Wei, Liang Liu, Xiaoqing Wang, Bin Zong, Xuekui Liu, Miaomiao Zhang, Qiang Fu, Liansheng Wang, Bangming Cao
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: ESC Heart Failure, Vol 10, Iss 1, Pp 303-310 (2023)
Druh dokumentu: article
ISSN: 2055-5822
DOI: 10.1002/ehf2.14147
Popis: Abstract Aims Identification and intervention of left ventricular hypertrophy (LVH) in essential hypertension (EH) are important for the prevention of adverse cardiovascular events. However, effective methods for diagnosing LVH are still lacking. This study aimed to explore the relationship between soluble ST2 (sST2) and LVH in EH patients to identify a potential specific biomarker for hypertensive LVH. Methods and results This study included 97 EH patients. Based on the criteria for LVH, participants were divided into the LVH group (n = 52) and the non‐LVH group (n = 45). The level of serum sST2 was detected by enzyme‐linked immunosorbent assay. Pearson correlation analysis, logistic regression analysis, and receiver operating characteristic (ROC) curve analysis were used to investigate the potential of sST2 as a biomarker of LVH in EH patients. Compared with the non‐LVH group, the sST2 level was elevated in EH patients with LVH (P
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