The influence of Schiff base inclusion complexes with β-cyclodextrine on antibiotic production by Streptomyces hygroscopicus CH-7
| Autor: | Ilić Slavica B., Konstantinović Sandra S., Gojgić-Cvijović G., Savić Dragiša S., Veljković Vlada B. |
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| Jazyk: | English<br />Serbian |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Hemijska Industrija, Vol 69, Iss 1, Pp 9-15 (2015) |
| Druh dokumentu: | article |
| ISSN: | 0367-598X 2217-7426 |
| DOI: | 10.2298/HEMIND131113012I |
| Popis: | A media consisting of isatin-Schiff bases and its inclusion complexes with β-cyclodextrine was developed to maximize the production of antibiotics Hexaene H-85 and Azalomycine β by Streptomyces hygroscopicus CH-7. The media with β-cyclodextrine inclusion complex of isatin-3-thiosemicarbazone resulted in the maximum antibiotics concentration of 493 µg/cm3 for Hexaene H-85 and 191 µg/cm3 for Azalomycine B. The production of Hexaene H-85 and Azalomycine is higher when β-cyclodextrine complex is added as a nitrogen source, comparing to pure isatin-Schiff base. The maximum concentration of hexaene H-85 in medium with inclusion complex of isatin-Schiff base is 1.4-2.3 times higher than the basal medium. The maximum production of Azalomycine is 2.1-3.4 times higher in media with inclusion complex of Schiff base. During the fermentation process, the nutrient media with β-cyclodextrine inclusion complexes with isatin-Schiff bases affect the strain morphology, since it is in the form of compact pellets, which are formed from short and long, branched filaments [Projekat Ministarstva nauke Republike Srbije, br. III 45001] |
| Databáze: | Directory of Open Access Journals |
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