Tumor-infiltrating CD36+CD8+T cells determine exhausted tumor microenvironment and correlate with inferior response to chemotherapy in non-small cell lung cancer

Autor:	Yong-Qiang Ao, Jian Gao, Ling-Xian Zhang, Jie Deng, Shuai Wang, Miao Lin, Hai-Kun Wang, Jian-Yong Ding, Jia-Hao Jiang
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	NSCLC CD36+CD8+ T cells Tumor microenvironment Prognosis Chemotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	BMC Cancer, Vol 23, Iss 1, Pp 1-13 (2023)
Druh dokumentu:	article
ISSN:	1471-2407
DOI:	10.1186/s12885-023-10836-z
Popis:	Abstract Background The scavenger receptor CD36 was reported to be highly expressed on tumor-infiltrating CD8+ T cells, but the clinical role remains obscure. This study aims to explore the infiltration and clinical value of CD36+CD8+ T cells in NSCLC. Methods Immunohistochemistry and immunofluorescence were conducted for survival analyses and immunological evaluation in 232 NSCLC patients in Zhongshan Hospital. Flow cytometry analyses were carried out to assess the immune cells from fresh tumor samples, non-tumor tissues and peripheral blood. In vitro tumor infiltrating lymphocytes cultures were conducted to test the effect of CD36 blockage. Results Accumulation of CD36+CD8+ T cells in tumor tissues was correlated with more advanced stage (p
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