Application of a 3D bioprinter: jet technology for ‘biopatch’ development using cells on hydrogel supports
| Autor: | Derek C DeMel, Grayson A Wagner, Jamie A Maresca, John P Geibel |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | BioTechniques (2023) |
| Druh dokumentu: | article |
| ISSN: | 2023-0052 1940-9818 0736-6205 |
| DOI: | 10.2144/btn-2023-0052 |
| Popis: | Additive manufacturing (3D printing) has been deployed across multiple platforms to fabricate bioengineered tissues. We demonstrate the use of a Thermal Inkjet Pipette System (TIPS) for targeted delivery of cells onto manufactured substrates to design bio-bandages. Two cell lines – HEK 293 (kidney) and K7M2 wt (bone) – were applied using TIPS. We demonstrate a novel means for targeted cell delivery to a hydrogel support structure. These cell/support constructs (bio-bandages) had a high viability for survival and growth over extended periods. Combining a flexible biosupport with application of cells via TIPS printing now for the first time allows for custom cell substrate constructs with various densities to be deployed for regenerative medicine applications. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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