Development and pilot evaluation of an evidence-based algorithm for MASLD (formerly NAFLD) management in primary care in Europe

Autor: Marilena Anastasaki, Sophia Papadakis, Irini N. Gergianaki, Loucas Papastamatiou, Eftychios Aligizakis, Nikoleta Grillaki, Eleni Boutzoukaki, Nektarios Sivaropoulos, Foteini Anastasiou, Juan Mendive, Carlos de Juan-Asenjo, Rosario Hernández-Ibáñez, Alba Martínez-Escudé, Montserrat Garcia-Retortillo, Ger Koek, Leen Heyens, Jean Muris, Christos D. Lionis
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Medicine, Vol 11 (2024)
Druh dokumentu: article
ISSN: 2296-858X
DOI: 10.3389/fmed.2024.1383112
Popis: BackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD), emerges as major cause of morbidity and mortality globally, with chronic patients facing increased risk. Guidelines on MASLD management in primary care (PC) are limited. This study aimed to develop and evaluate a clinical care pathway for use in PC to improve MASLD screening and management, including early detection, communication and treatment, in three European countries (Greece, Spain, the Netherlands).MethodsAn international multidisciplinary panel of experts oversaw pathway development, which was designed as a two-step algorithm with defined and sequenced tasks. To evaluate algorithm implementation, a controlled pilot study was conducted. Patients at risk of MASLD were assigned to general practitioners (GPs) trained in algorithm implementation (active group) or usual care (control group) and followed for 4–8 weeks. Primary outcomes were the number of patients screened for MASLD, managed in PC and referred to specialists.ResultsIn this algorithm, patients with metabolic or liver dysfunction, confirmed MASLD or cardiovascular disease are screened with FIB-4 and classified as having risk of low-level (FIB-4
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