Dual-pathway Inhibition with Low-dose Aspirin and Rivaroxaban versus Aspirin Monotherapy in Patients with Coronary Artery Disease and Peripheral Artery Disease: Systematic Literature Review and Meta-analysis
| Autor: | Dirk Sibbing, Michael J Blaha, Rajinder Chawla, Augusto Lavalle-Cobo, Amit Kishore, Angel Lanas, Li Li, Francesca Santilli, Oliver Schnell, Zhongwei Shi |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | European Cardiology Review, Vol 19, Iss , Pp - (2024) |
| Druh dokumentu: | article |
| ISSN: | 1758-3764 1758-3756 |
| DOI: | 10.15420/ecr.2023.40 |
| Popis: | Background: Low-dose aspirin lowers cardiovascular event risk; dual-pathway inhibition (DPI) using low-dose aspirin with low-dose rivaroxaban may reduce this risk further. A systematic literature review and meta-analysis compared the efficacy, safety and net clinical benefit (NCB) of DPI with aspirin. Methods: PubMed and Embase were searched for randomised controlled trials reporting clinical efficacy, safety and NCB of DPI compared with aspirin alone in patients with coronary artery disease (CAD) and/or peripheral artery disease. Six articles representing four trials were included. Results: DPI versus aspirin alone significantly reduced major adverse cardiovascular events (HR 0.77; 95% CI [0.69–0.87]; p |
| Databáze: | Directory of Open Access Journals |
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