| Autor: |
Liang-Liang Sun, Jian Wang, Yu-Sheng Wang, Xiao Pan, Jun Luo, Hua Liu, Yi-Rou Jiang, Xin Zhuang, Liang Lin, Gan-Cheng Li, Jun-Wei Zhao, Wei Wang, Yuan-Jing Wang, Zhi-Hao Wang, Hong-Biao Shan, Shuai-Shuai Chen, Jun-Lin Chen, Zhao-Wei Xu, Yong-Hai Bai, Hai Huang, Wei-Fen Xie |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Frontiers in Medicine, Vol 9 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2296-858X |
| DOI: |
10.3389/fmed.2022.854788 |
| Popis: |
ObjectiveThe long-term impact of COVID-19 on patient health has been a recent focus. This study aims to determine the persistent symptoms and psychological conditions of patients hospitalized with COVID-19 15 months after onset, that patients first developed symptoms. The potential risk factors were also explored.MethodsA cohort of COVID-19 patients discharged from February 20, 2020 to March 31, 2020 was recruited. Follow-ups were conducted using validated questionnaires and psychological screening scales at 15 months after onset to evaluate the patients' health status. The risk factors for long-term health impacts and their associations with disease severity was analyzed.Findings534 COVID-19 patients were enrolled. The median age of the patients was 62.0 years old (IQR 52.0–70.0) and 295 were female (55.2%). The median time from onset to follow-up was 460.0 (451.0–467.0) days. Sleep disturbance (18.5%, 99/534) and fatigue (17.2%, 92/534) were the most common persistent symptoms. 6.4% (34/534) of the patients had depression, 9.2% (49/534) were anxious, 13.0% (70/534) had insomnia and 4.7% (25/534) suffered from post-traumatic stress disorder (PTSD). Multivariate adjusted logistic regression analysis showed that glucocorticoid use during hospitalization (OR 3.58, 95% CI 1.12–11.44) was significantly associated with an increased risk of fatigue. The OR values for anxiety and sleep disorders were 2.36 (95% CI 1.07–5.20) and 2.16 (95% CI 1.13–4.14) in females to males. The OR value of PTSD was 25.6 (95% CI 3.3–198.4) in patients with persistent symptoms to those without persistent symptoms. No significant associations were observed between fatigue syndrome or adverse mental outcomes and disease severity.Conclusions15-month follow-up in this study demonstrated the need of extended rehabilitation intervention for complete recovery in COVID-19 patients. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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