| Autor: |
Kostiantyn O. Marichev, Kuiyong Dong, Lynée A. Massey, Yongming Deng, Luca De Angelis, Kan Wang, Hadi Arman, Michael P. Doyle |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-019-13326-8 |
| Popis: |
Chiral 3-azetidinones are structural analogues of medicinally relevant β-lactams, however their synthesis and reactivity are underexplored. Here, the authors show a highly enantioselective copper-catalyzed [3 + 1]-cycloaddition generating 2-azetidines, which react with nucleophiles yielding amino acids via 3-azetidinones. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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