| Autor: |
Jikui Guan, Ganesh Umapathy, Yasuo Yamazaki, Georg Wolfstetter, Patricia Mendoza, Kathrin Pfeifer, Ateequrrahman Mohammed, Fredrik Hugosson, Hongbing Zhang, Amy W Hsu, Robert Halenbeck, Bengt Hallberg, Ruth H Palmer |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
eLife, Vol 4 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
2050-084X |
| DOI: |
10.7554/eLife.09811 |
| Popis: |
Aberrant activation of anaplastic lymphoma kinase (ALK) has been described in a range of human cancers, including non-small cell lung cancer and neuroblastoma (Hallberg and Palmer, 2013). Vertebrate ALK has been considered to be an orphan receptor and the identity of the ALK ligand(s) is a critical issue. Here we show that FAM150A and FAM150B are potent ligands for human ALK that bind to the extracellular domain of ALK and in addition to activation of wild-type ALK are able to drive 'superactivation' of activated ALK mutants from neuroblastoma. In conclusion, our data show that ALK is robustly activated by the FAM150A/B ligands and provide an opportunity to develop ALK-targeted therapies in situations where ALK is overexpressed/activated or mutated in the context of the full length receptor. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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