Acid‐base imbalances and the association of blood‐gas variables, electrolytes, and biochemical analytes with outcome in hospitalized calves undergoing abdominal surgery

Autor: Florian M. Trefz, Corinna K. Lausch, Anna Rieger, Stine Giertzuch, Annette Lorch, Peter D. Constable
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Veterinary Internal Medicine, Vol 37, Iss 2, Pp 740-756 (2023)
Druh dokumentu: article
ISSN: 1939-1676
0891-6640
DOI: 10.1111/jvim.16618
Popis: Abstract Background Surgical abdominal emergencies in calves are associated with a guarded prognosis and have the potential for complex metabolic derangements including acid‐base imbalances. Objectives To perform a comprehensive analysis of acid‐base status and to assess the prognostic relevance of preoperative clinicopathologic variables in calves undergoing abdominal surgery. Animals Hospital‐based study samples of 535 (dataset 1; DS1) and 83 calves (dataset 2; DS2). Methods Retrospective (DS1) and prospective (DS2) case series. Results In DS1, acidemia (pH 7.37) was present in 30.7% of calves. Plasma L‐lactate, chloride, and serum inorganic phosphorus concentration accounted for 51.9%, 11.6% and 9.4% of the variation of venous blood pH, respectively. Classification tree analysis indicated that a negative outcome (death or euthanasia during hospitalization) was associated with venous pO2 ≤33.6 mm Hg, anion gap >18.3 and >22.9 mEq/L, serum albumin concentration ≤36.5 and ≤29.4 g/L, serum urea concentration >4.4 mmol/L, and plasma ionized calcium concentration ≤1.26 mmol/L. The area under the receiver operating characteristic curve of this model was 0.85 (95% CI: 0.82‐0.89, P
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