| Autor: |
Xingrui He, Xiao-Tao Zhuo, Yuan Gao, Renren Bai, Xiang-Yang Ye, Tian Xie |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Royal Society Open Science, Vol 7, Iss 5 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2054-5703 |
| DOI: |
10.1098/rsos.200038 |
| Popis: |
Herein, we report the first access of β-elemene derivatives through the SeO2-mediated oxidation reaction. Several new compounds were isolated through such a one-step reaction, and their structures were elucidated using various 2D-NMR techniques. This method provides easy access to multiple oxidative β-elemene derivatives in one single step and represents the first modifications on cyclohexyl ring of β-elemene. It is expected to open up the opportunity for future derivatization on cyclohexyl ring of β-elemene. The new compounds obtained above showed better anti-proliferation activities than β-elemene itself on several cancer cell lines. Among them, compound 17 shows the best activity in antiproliferation assays of A549 and U-87MG cell lines. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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