Adverse cutaneous drug reactions to fixed dose combination tablet of antituberculous drugs: a case series

Autor: Manju Mohan, Bindurani S, Anupa Mary Job, Deepa B, S. N. Mohanasundaram
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Krishna Institute of Medical Sciences University, Vol 11, Iss 2, Pp 105-107 (2022)
Druh dokumentu: article
ISSN: 2231-4261
Popis: Tuberculosis, an infectious disease caused by Mycobacterium tuberculosis is very common in India. The treatment of tuberculosis consists of multiple drugs which are given as fixed dose combinations with all the drugs in a single tablet. Adverse drug reaction to these drugs is common and rechallenging is the only way to find the incriminating drug. But in a few cases, no drugs were found as the incriminating agent and the patients completed the treatment with individual component drugs without any adverse drug reaction. The reason is probably the excipients like colouring agent added to the fixed dose combination which could have provoked the allergic reaction. This case series reports four such cases in which excipient would have caused the adverse drug reaction.
Databáze: Directory of Open Access Journals