| Autor: |
Iosif B. Mikhel, Elena O. Bakhrushina, Danila A. Petrusevich, Andrey A. Nedorubov, Svetlana A. Appolonova, Natalia E. Moskaleva, Natalia B. Demina, Svetlana I. Kosenkova, Mikhail A. Parshenkov, Ivan I. Krasnyuk |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Pharmaceutics, Vol 16, Iss 9, p 1125 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1999-4923 |
| DOI: |
10.3390/pharmaceutics16091125 |
| Popis: |
Recently, ribavirin has demonstrated effectiveness in treating glioblastoma through intranasal administration utilizing the nose-to-brain delivery route. Enhancing ribavirin’s bioavailability can be achieved by utilizing intranasal stimuli-responsive systems that create a gel on the nasal mucosa. The research examined thermosensitive, pH-sensitive, and ion-selective polymers in various combinations and concentrations, chosen in line with the current Quality by Design (QbD) approach in pharmaceutical development. Following a thorough assessment of key parameters, the optimal composition of gellan gum at 0.5%, Poloxamer 124 at 2%, and purified water with ribavirin concentration at 100 mg/mL was formulated and subjected to in vivo testing. Through experiments on male rats, the nose-to-brain penetration mechanism of the active pharmaceutical ingredient (API) was elucidated, showcasing drug accumulation in the olfactory bulbs and brain. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
