| Autor: |
David P Sargeant, Michael W Hedden, Sandeep Deverasetty, Christy L Strong, Izua J Alaniz, Alexandria N Bartlett, Nicholas R Brandon, Steven B Brooks, Frederick A Brown, Flaviona Bufi, Monika Chakarova, Roxanne P David, Karlyn M Dobritch, Horacio P Guerra, Kelvy S Levit, Kiran R Mathew, Ray Matti, Dorothea Q Maza, Sabyasachy Mistry, Nemanja Novakovic, Austin Pomerantz, Timothy F Rafalski, Viraj Rathnayake, Noura Rezapour, Christian A Ross, Steve G Schooler, Sarah Songao, Sean L Tuggle, Helen J Wing, Sandy Yousif, Martin R Schiller |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 9, Iss 3, p e92877 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0092877 |
| Popis: |
We present a new approach for pathogen surveillance we call Geogenomics. Geogenomics examines the geographic distribution of the genomes of pathogens, with a particular emphasis on those mutations that give rise to drug resistance. We engineered a new web system called Geogenomic Mutational Atlas of Pathogens (GoMAP) that enables investigation of the global distribution of individual drug resistance mutations. As a test case we examined mutations associated with HIV resistance to FDA-approved antiretroviral drugs. GoMAP-HIV makes use of existing public drug resistance and HIV protein sequence data to examine the distribution of 872 drug resistance mutations in ∼ 502,000 sequences for many countries in the world. We also implemented a broadened classification scheme for HIV drug resistance mutations. Several patterns for geographic distributions of resistance mutations were identified by visual mining using this web tool. GoMAP-HIV is an open access web application available at http://www.bio-toolkit.com/GoMap/project/ |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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