Effect of liver dysfunction on outcome of radioactive iodine therapy for Graves’ disease

Autor: Yuyang Ze, Fei Shao, Xuefeng Feng, Shanmei Shen, Yan Bi, Dalong Zhu, Xiaowen Zhang
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: BMC Endocrine Disorders, Vol 22, Iss 1, Pp 1-9 (2022)
Druh dokumentu: article
ISSN: 1472-6823
DOI: 10.1186/s12902-022-01242-w
Popis: Abstract Liver dysfunction is a common complication of Graves’ disease (GD) that may be caused by excessive thyroid hormone (TH) or anti-thyroid drugs (ATDs). Radioactive iodine (RAI) therapy is one of the first-line treatments for GD, but it is unclear whether it is safe and effective in patients with liver dysfunction. 510 consecutive patients with GD receiving first RAI were enrolled in the study, and followed up at 3-, 6- and 12-month. Liver dysfunction was recorded in 222 (43.5%) patients. GD patients with liver dysfunction had higher serum levels of free triiodothyronine (FT3) (median 27.6 vs. 20.6 pmol/L, p
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