An Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Catalyzed by a Novel Brønsted Acidic Ionic Liquid under Solvent-Free Conditions

Autor: Yonghong Zhang, Bin Wang, Xiaomei Zhang, Jianbin Huang, Chenjiang Liu
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Molecules, Vol 20, Iss 3, Pp 3811-3820 (2015)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/molecules20033811
Popis: We report here an efficient and green method for Biginelli condensation reaction of aldehydes, β-ketoesters and urea or thiourea catalyzed by Brønsted acidic ionic liquid [Btto][p-TSA] under solvent-free conditions. Compared to the classical Biginelli reaction conditions, the present method has the advantages of giving good yields, short reaction times, near room temperature conditions and the avoidance of the use of organic solvents and metal catalyst.
Databáze: Directory of Open Access Journals