| Autor: |
Pragalv Karki, Stephanie Sincomb, Matthew C. Murphy, Jeffrey L. Gunter, Matthew L. Senjem, Jonathan Graff-Radford, David T. Jones, Hugo Botha, Jeremy K. Cutsforth-Gregory, Benjamin D. Elder, John Huston, III, Petrice M. Cogswell |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Brain Multiphysics, Vol 7, Iss , Pp 100101- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2666-5220 |
| DOI: |
10.1016/j.brain.2024.100101 |
| Popis: |
Background and purpose: Idiopathic normal pressure hydrocephalus (iNPH) is a cerebrospinal fluid (CSF) dynamics disorder as evidenced by the delayed ascent of radiotracers over the cerebral convexity on radionuclide cisternography. However, the exact mechanism causing this disruption remains unclear. Elucidating the pathophysiology of iNPH is crucial, as it is a treatable cause of dementia. Improving the diagnosis and treatment prognosis rely on the better understanding of this disease. In this study, we calculated the pulsatile transmantle pressure and investigated the phase lag between this pressure and the volumetric CSF flow rate as a novel biomarker of CSF dynamics disruption in iNPH. Methods: 44 iNPH patients and 44 age- and sex-matched cognitively unimpaired (CU) control participants underwent MRI scans on a 3T Siemens scanner. Pulsatile transmantle pressure was calculated analytically and computationally using volumetric CSF flow rate, cardiac frequency, and aqueduct dimensions as inputs. CSF flow rate through the aqueduct was acquired using phase-contrast MRI. The aqueduct length and radius were measured using 3D T1-weighted anatomical images. Results: Peak pressure amplitudes and the pressure load (integrated pressure exerted over a cardiac cycle) were similar between the groups, but the non-dimensionalized pressure load (adjusted for anatomical factors) was significantly lower in the iNPH group (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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