| Autor: |
Johannes F. Imhoff, Kerstin Nagel, Jutta Wiese, Rüdiger Stöhr, Stefanie Schmitt, Gerhard Lang, Tobias A. M. Gulder, Gerhard Bringmann |
| Jazyk: |
angličtina |
| Rok vydání: |
2007 |
| Předmět: |
|
| Zdroj: |
Marine Drugs, Vol 5, Iss 2, Pp 23-30 (2007) |
| Druh dokumentu: |
article |
| ISSN: |
1660-3397 |
| DOI: |
10.3390/md502023 |
| Popis: |
In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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