Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance

Autor:	Yunfu Lv, Yejuan Li, XiaoYu Han, Ning Liu, Min Zeng
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	liver cirrhosis with hypersplenism animal experiment spleen fibrosis chemotactic axis cxcl12-cxcr4/cxcr7 therapeutic significance Medicine
Zdroj:	Archives of Medical Science, Vol 19, Iss 5, Pp 1569-1575 (2023)
Druh dokumentu:	article
ISSN:	1734-1922 1896-9151
DOI:	10.5114/aoms/170910
Popis:	Introduction To investigate the expression and treatment of chemokine CXCL12 and its receptor CXCR4/CXCR7. Methods The liver cirrhosis hypersplenism model of rats was made with CCL4, and then was detected by immunohistochemistry, Western blot and qRT-PCR. Results The area of spleen fibrosis in the model group was significantly larger than that in the control group (p < 0.01), and the expression of CXCL12, CXCR4 and CXCR7 in the model group was significantly higher than that in the control group (p < 0.01). Conclusions CXCL12-CXCR4/CXCR7 is abnormally high in splenic fibrosis, and blocking its high expression can slow down the occurrence of hypersplenism.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/e21bf7b22c454144ba29bacc598a20e8 Zobrazit plný text záznamu View record in DOAJ