Proteomics based markers of clinical pain severity in juvenile idiopathic arthritis

Autor:	Hanne Van Der Heijden, Benoit Fatou, Diana Sibai, Kacie Hoyt, Maria Taylor, Kin Cheung, Jordan Lemme, Mariesa Cay, Benjamin Goodlett, Jeffery Lo, Melissa M. Hazen, Olha Halyabar, Esra Meidan, Rudy Schreiber, Camilo Jaimes, Kirsten Ecklund, Lauren A. Henderson, Margaret H. Chang, Peter A. Nigrovic, Robert P. Sundel, Hanno Steen, Jaymin Upadhyay
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Proteomics Mass spectrometry Juvenile idiopathic arthritis Pain Inflammation Pediatrics RJ1-570 Diseases of the musculoskeletal system RC925-935
Zdroj:	Pediatric Rheumatology Online Journal, Vol 20, Iss 1, Pp 1-10 (2022)
Druh dokumentu:	article
ISSN:	1546-0096
DOI:	10.1186/s12969-022-00662-1
Popis:	Highlights In the current preliminary study, serum proteins associated with pain severity were identified in JIA patients. Pain-associated proteins had functional roles predominantly in immune or inflammatory processes. Correlations of pain-associated proteins with ESR and altered CNS morphology were also observed with ESR and altered CNS morphology were also observed. Larger-scale as well as longitudinal studies are needed to determine if evaluation of the proteome may provide a platform for identifying novel analgesic targets in JIA.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/21b59a1608ff4d0b8f510734562c6859 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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