Integrating gene expression and clinical data to identify drug repurposing candidates for hyperlipidemia and hypertension

Autor:	Patrick Wu, QiPing Feng, Vern Eric Kerchberger, Scott D. Nelson, Qingxia Chen, Bingshan Li, Todd L. Edwards, Nancy J. Cox, Elizabeth J. Phillips, C. Michael Stein, Dan M. Roden, Joshua C. Denny, Wei-Qi Wei
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Science
Zdroj:	Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Druh dokumentu:	article
ISSN:	2041-1723 05639042
DOI:	10.1038/s41467-021-27751-1
Popis:	Prioritizing drug repurposing candidates for downstream studies remains challenging. Here, the authors present a high-throughput approach to identify and validate drug repurposing candidates, integrating human gene expression, drug perturbation, and clinical data from publicly available resources.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/21ab9d056390420ba81493fa1607bba7 Zobrazit plný text záznamu Full text from SpringerLink View record in DOAJ