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Objective To analyze the high risk factors and nursing intervention measures of acquired weakness in intensive care unit (ICU-AW). Methods The clinical data of 261 patients with critically ill admitted to the ICU of our hospital from January 2023 to December 2023 were collected retrospectively. They were divided into the ICU-AW group (115 cases) and the non-ICU-AW group (146 cases) according to whether the patients were complicated with ICU-AW. The statistically significant factors were included in multivariate Logistic regression analysis to further analyze the risk factors of ICU-AW in patients with critically ill according to the clinical data of patients. Results Among 261 patients with critically ill, 115 patients had ICU-AW, and the incidence of ICU-AW was 44. 06%. The results of multivariate Logistic regression analysis showed that high score of acute physiological and chronic health status (score of APACHE II) and level of blood lactic acid , long time of ICU stay , and time of mechanical ventilation, diagnosis of multiple organ dysfunction, continuous renal replacement therapy and application of hormone drugs were independent risk factors for ICU-AW in patients with critically ill (OR= 3. 086, 4. 297, 1. 958, 3. 180, 3. 736, 3. 658, 4. 031, P |