Inflammation‐associated intramyocellular lipid alterations in human pancreatic cancer cachexia

Autor: Min Deng, Jianhua Cao, Gregory van derKroft, David P.J. vanDijk, Merel R. Aberle, Andrej Grgic, Ulf P. Neumann, Georg Wiltberger, Benjamin Balluff, Frank G. Schaap, Ron M.A. Heeren, Steven W.M. Olde Damink, Sander S. Rensen
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 4, Pp 1283-1297 (2024)
Druh dokumentu: article
ISSN: 2190-6009
2190-5991
DOI: 10.1002/jcsm.13474
Popis: Abstract Background Cancer cachexia is a multifactorial metabolic syndrome characterized by systemic inflammation and ongoing skeletal muscle loss resulting in weakness, poor quality of life, and decreased survival. Whereas lipid accumulation in skeletal muscle is associated with cancer cachexia as well as the prognosis of cancer patients, surprisingly little is known about the nature of the lipids that accumulate in the muscle during cachexia, and whether this is related to inflammation. We aimed to identify the types and distributions of intramyocellular lipids in patients with and without cancer cachexia. Methods Rectus abdominis muscle biopsies were collected during surgery of patients with pancreatic ductal adenocarcinoma (n = 10 without cachexia, n = 20 cachectic without inflammation (CRP
Databáze: Directory of Open Access Journals
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