Leukocyte telomere dynamics across gestation in uncomplicated pregnancies and associations with stress

Autor: Danielle M. Panelli, Stephanie A. Leonard, Ronald J. Wong, Martin Becker, Jonathan A. Mayo, Erica Wu, Anna I. Girsen, Ian H. Gotlib, Nima Aghaeepour, Maurice L. Druzin, Gary M. Shaw, David K. Stevenson, Katherine Bianco
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: BMC Pregnancy and Childbirth, Vol 22, Iss 1, Pp 1-12 (2022)
Druh dokumentu: article
ISSN: 1471-2393
DOI: 10.1186/s12884-022-04693-0
Popis: Abstract Background Short leukocyte telomere length is a biomarker associated with stress and morbidity in non-pregnant adults. Little is known, however, about maternal telomere dynamics in pregnancy. To address this, we examined changes in maternal leukocyte telomere length (LTL) during uncomplicated pregnancies and explored correlations with perceived stress. Methods In this pilot study, maternal LTL was measured in blood collected from nulliparas who delivered live, term, singleton infants between 2012 and 2018 at a single institution. Participants were excluded if they had diabetes or hypertensive disease. Samples were collected over the course of pregnancy and divided into three time periods:
Databáze: Directory of Open Access Journals
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