Syntheses and evaluation of multicaulin and miltirone-like compounds as antituberculosis agents

Autor:	Serdar Burmaoğlu, Hatice Seçinti, Erkan Mozioğlu, Ahmet C. Gören, Ramazan Altundaş, Hasan Seçen
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	Multicaulin miltirone synthesis antituberculosis Therapeutics. Pharmacology RM1-950
Zdroj:	Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 878-884 (2017)
Druh dokumentu:	article
ISSN:	1475-6366 1475-6374 14756366
DOI:	10.1080/14756366.2017.1337758
Popis:	Four multicaulin and miltirone-like phenanthrene derivatives were synthesised and evaluated as antituberculosis agents. The crucial step of the synthesis was Pschorr coupling of 4-(3-isopropyl-4-methoxyphenyl)-2-(2-aminophenyl)ethane (13) to give 2-isopropyl-3-methoxy-9,10-dihydrophenanthrene (9) and 4-isopropyl-3-methoxy-9,10-dihydrophenanthrene (9a). Compound 9 was converted to multicaulin and miltirone-like phenanthrene derivatives by further reactions. The best antituberculosis activity was exhibited by 2-isopropylphenanthrene-3-ol (11).
Databáze:	Directory of Open Access Journals
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