| Autor: |
Jiyuan Zou, Han Xia, Qianzhou Jiang, Zhikang Su, Siyi Wen, Zitian Liang, Yuanting Ouyang, Jiaohong Liu, Zhiyi Zhang, Ding Chen, Li Yang, Lvhua Guo |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Regenerative Therapy, Vol 24, Iss , Pp 135-146 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2352-3204 |
| DOI: |
10.1016/j.reth.2023.05.008 |
| Popis: |
Odontogenic stem cells originate from cranial neural crest cells and offer unique advantages in the regeneration of dentin-pulp complex. There is increasing evidence that stem cells exert their biological functions mainly through exosome-based paracrine effects. Exosomes contain DNA, RNA, proteins, metabolites, etc., which can play a role in intercellular communication and have similar therapeutic potential to stem cells. In addition, compared with stem cells, exosomes also have the advantages of good biocompatibility, high drug carrying capacity, easy to obtain, and few side effects. Odontogenic stem cell-derived exosomes mainly affect the regeneration of the dentin-pulp complex by regulating processes such as dentintogenesis, angiogenesis, neuroprotection and immunomodulation. This review aimed to describe “cell-free therapies” based on odontogenic stem cell-derived exosomes, which aim to regenerate the dentin-pulp complex. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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