| Autor: |
Samuel K. Appiah, Charles Nkansah, Kofi Mensah, Felix Osei-Boakye, Dorcas Serwaa, Simon B. Bani, Gabriel Abbam, Samira Daud, Mandeiya D. A. Yakubu, Abraham B. Sagoe, Charles A. Derigubah, Yeduah Quansah, Vincent Kawuribi |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
SciMedicine Journal, Vol 4, Iss 2, Pp 63-72 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2704-9833 |
| DOI: |
10.28991/SciMedJ-2022-04-02-02 |
| Popis: |
Background: The ABO blood antigens may influence the levels of vWF: Ag and put individuals at risk of coagulopathies. This study assessed the plasma vWF: Ag and its relation with ABO blood antigens among healthy adults in northern Ghana. Methods: This cross-sectional study recruited 84 blood donors, aged 18–50 years, at Tamale Teaching Hospital. Blood groups were determined using the standard tube method, and a complete blood count was measured with an automated haematology analyzer. Sandwich ELISA was used to assess plasma vWF: Ag levels. The data obtained were analyzed using SPSS version 22. Results: The frequencies of O, A, B, and AB blood groups were 34 (40.5%), 25 (29.8%), 20 (23.8%), and 5 (6.0%), respectively. vWF: Ag levels were higher among the non-O than group O individuals (p = 0.008). Plasma vWF: Ag levels were lower in group O compared to AB (p = 0.015) and A (p = 0.013) individuals. Males had higher vWF: Ag levels than females (p = 0.002). A moderately positive correlation was observed between age and vWF levels (r = 0.497, pA>B>AB. Plasma vWF: Ag levels were higher in non-group O compared with group O individuals. Males had higher vWF: Ag levels, and a positive correlation between age and vWF: Ag was observed. Again, blood group O participants had lower neutrophil counts, but higher RDW-SD. The relationship between ABO blood phenotypes and plasma vWF: Ag should be considered in clinical practice. The establishment of separate reference intervals of vWF: Ag for the various phenotypes of ABO is recommended. Also, the study recommends further multicenter studies to assess the link between ABO phenotypes and all the endothelial cell parameters. Doi: 10.28991/SciMedJ-2022-04-02-02 Full Text: PDF |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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