Тransplantation of autologous stem cells, obtained from adipose tissue, in complex treatment of chronic ischemia of the lower extremities
| Autor: | V. G. Mishalov, N. Yu. Litvinova, O. I. Kefeli-Yanovska, V. A. Chernyak, D. E. Dubenko, E. A. Dzhalilova, O. I. Azarov, R. F. Kaminsky |
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| Jazyk: | Russian<br />Ukrainian |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Клінічна хірургія, Vol 85, Iss 12, Pp 30-34 (2018) |
| Druh dokumentu: | article |
| ISSN: | 0023-2130 2522-1396 |
| DOI: | 10.26779/2522-1396.2018.12.30 |
| Popis: | Objective. To investigate the efficacy of application of autologous mesenchymal stem cells (AMSC) in treatment of patients, suffering critical ischemia of the lower extremities (CILE). Маterials and methods. In 2012 - 2015 yrs there was conducted the treatment of 41 patients, suffering CILE: 22 (53.7%) - men, and 19 (46.3%) - women. In the Group I (the main) 21 (51.2%) patients have had obtained a standard course of treatment, using AMSC. In the Group II (the control one) 20 (49.8%) patients have obtained a standard course of conservative treatment, using prostaglandins of group Е1 (PGЕ1). The results were investigated, measuring ankle-brachial pressure index, and the indices of a laser duplex flowmetry and a walking distance. Results. During a one-year follow-up a trustworthy enhancement of microcirculation index was registered in the patients, who were treated, using AMSC, comparing with the patients, who obtained a course of therapy of PGЕ1 (р=0.037). Positive dynamics of the microcirculation index while a PGЕ1application was observed during (1.8 ± 0.3) mo, аnd while application of AMSC the microcirculation index have been enhanced trustworthily in (2.7 ± 0.4) mo and persisted during one-year of follow-up. Conclusion. Development of therapeutic effect in groups of patients, who were treated with AMSC and PGЕ1, did not occur simultaneously, thus , a complex treatment with simultaneous application of both methods and conduction of a dosed physical training may be considered a rational option. |
| Databáze: | Directory of Open Access Journals |
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