| Autor: |
Ramin Nourinia, Zahra-Soheila Soheili, Hamid Ahmadieh, Hassan Akrami, Mozhgan Rezaei Kanavi, Shahram Samiei |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Journal of Ophthalmic & Vision Research, Vol 8, Iss 1, Pp 4-8 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
2008-322X |
| Popis: |
Purpose: To evaluate the effect of placental growth factor (PlGF) gene knockdown in a murine model of laser-induced choroidal neovascularization. Methods: Choroidal neovascularization was induced in the left eyes of 11 mice by infrared laser. Small interfering RNA (siRNA, 20 picomoles/10 μl) corresponding to PlGF mRNA was administered intravitreally by Hamilton syringe in all subjects. One month later, fluorescein angiography and histolologic examination were performed. Results: No leakage was apparent in the 11 eyes treated with siRNA cognate to PlGF. The results of histological evaluation were consistent with angiographic findings showing absence of choroidal neovascularization. Conclusion: Knockdown of the PlGF gene can inhibit the growth of laser-induced choroidal neovascularization in mice. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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