Attenuation of Seizures, Cognitive Deficits, and Brain Histopathology by Phytochemicals of (Poaceae) in Acute and Chronic Mutant Epilepsy Models
| Autor: | Fred Ssempijja MSc, PhD Fellow, Samuel Sunday Dare MSc, PhD Fellow, Edmund E. M. Bukenya PhD, Keneth Iceland Kasozi MSc, PhD Fellow, Ritah Kenganzi BSc, Edgar Mario Fernandez MSc, MMed, Marta Vicente-Crespo PhD |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Evidence-Based Integrative Medicine, Vol 28 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2515-690X 2515690X |
| DOI: | 10.1177/2515690X231160191 |
| Popis: | Imperata cylindrica is a globally distributed plant known for its antiepileptic attributes, but there is a scarcity of robust evidence for its efficacy. The study investigated neuroprotective attributes of Imperata cylindrica root extract on neuropathological features of epilepsy in a Drosophila melanogaster mutant model of epilepsy. It was conducted on 10-day-old (at the initiation of study) male post-eclosion bang-senseless paralytic Drosophila ( para bss1 ) involved acute (1-3 h) and chronic (6-18 days) experiments; n = 50 flies per group (convulsions tests); n = 100 flies per group (learning/memory tests and histological examination). Administrations were done in 1 g standard fly food, per os. The mutant flies of study ( para bss1 ) showed marked age-dependent progressive brain neurodegeneration and axonal degeneration, significant (P |
| Databáze: | Directory of Open Access Journals |
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